Recently large growing interest in ZnO worldwide in different fields because of it’s abundant applications like widely used as an additive in numerous materials and products including rubbers, plastics, ceramics, glass, cement, lubricants, paints, ointments, adhesives, sealants, pigments, food preservatives, batteries, ferrites, fire retardants, space craft coatings, first-aid tapes, health and environment applications. ZnO semiconductor has several favorable properties, including good transparency, high electron mobility, wide bandgap, and strong room-temperature luminescence. Those properties are valuable in emerging applications for: transparent electrodes in liquid crystal displays, energy-saving or heat-protecting windows, and electronics as thin-film transistors and light-emitting diodes.
Very largely, among other various organizations, especially in KFSSI research ZnO is used in various field of plasma technology and health applications.
Zinc materials were used by humans in processed and unprocessed forms, as a paint or medicinal ointment. The use of pushpanjan, probably zinc oxide, as a salve for eyes and open wounds, is mentioned in the Indian medical text the Charaka Samhita, thought to date from 500 BC or before ZnO ointment is also mentioned by the Greek physician Dioscorides (1st century AD.) Avicenna mentions ZnO in The Canon of Medicine (1025 AD), which mentioned it as a preferred treatment for a variety of skin conditions, including skin cancer. Though it is no longer used for treating skin cancer, it is still widely used to treat a variety of other skin conditions, in products such as baby powder and creams against diaper rashes, calamine cream, anti-dandruff shampoos, and antiseptic ointments.
The main usage of ZnO was in paints and as an additive to ointments. ZnO is widely used to treat a variety of skin conditions, including dermatitis, itching due to eczema, diaper rash and acne. This review analyzes the biomedical applications of metal oxide and ZnO nanomaterials under development at the experimental, preclinical, and clinical levels. A discussion regarding the advantages approaches, and limitations surrounding the use of metal oxide nanoparticles for cancer applications and drug delivery is presented. The scope of this article is focused on ZnO, and other metal oxide nanomaterial systems, and their proposed mechanisms of cytotoxic action, as well as current approaches, to improve their targeting and cytotoxicity against cancer cells. Materials where at least one dimension of the structure is less than 100 nm. This ultra-small size is comparable to naturally occurring proteins and biomolecules in the cell and is notably smaller than the typical diameter (~7 μm) of many human cells. The reduction of materials to the nanoscale can frequently alter their electrical, magnetic, structural, morphological, and chemical properties enabling them to interact in unique ways with cell biomolecules and enable their physical transport into the interior structures of cells. In a recent report, particles of 100–200 nm size showed a 4-fold higher rate of tumor uptake compared to particles greater than 300 nm, or less than 50 nm in size. Although smaller nanoparticles don’t readily make use of the EPR/enhanced permeation and retention effect, they typically exhibit more nanotoxicity related to their larger surface area/volume ratio. The electrostatic nature of nanoparticles is another important consideration, as electrostatic interactions between positively charged nanomaterial’s and target cells are believed to play an important part in cellular adhesion and uptake. The primary means by which inadvertent nanoparticle exposure in humans can occur is via inhalation, ingestion, or dermal contact.
Zinc is naturally present in rocks, soil, air, water, and the biosphere, as well as in plants, animals, and humans. In fact, zinc is essential to life as all organisms require it to survive and complete normal physiological functions. The metal also has a flexible coordination geometry, which allows proteins using it to rapidly shift conformations to perform biological reactions. Two examples of zinc containing enzymes are carbonic anhydrase and carboxypeptidase, which are vital to the processes of carbon dioxide (CO2) regulation and digestion of proteins, respectively. Carbonic anhydrase is important in the transport of carbon dioxide in the vertebrate blood. Even though zinc is an essential requirement for a healthy body, too much zinc can be harmful. Excessive absorption of zinc can also suppress copper and iron absorption. Zinc, a divalent cation, is an essential micronutrient for humans and its importance can be gauged from the fact that it is an essential component of more than 300 metalloenzymes and over 2000 transcription factors that are needed for regulation of lipid, protein and nucleic acid metabolism, and gene transcription. Zinc also plays an important role in maintaining the proper reproductive function, immune status, and wound repair via regulation of DNA and RNA polymerases, thymidine kinase, and ribonuclease. Groups at risk for zinc deficiency include the elderly, vegetarians, and those with renal insufficiency. The Age-Related Eye Disease Study determined that zinc could be part of an effective treatment for age-related macular degeneration.
Zinc is involved in numerous aspects of cellular metabolism. It was estimated that about 10% of human proteins potentially bind zinc, in addition to hundreds which transport and traffic zinc. It is required for the catalytic activity of more than 200 enzymes and it plays a role in immune function, wound healing, protein synthesis, DNA synthesis and cell division. Zinc is required for proper sense of taste and smell and supports normal growth and development during pregnancy, childhood, and adolescence. It is believed to possess antioxidant properties, which may protect against accelerated aging and helps speed up the healing process after an injury; however, studies differ as to its effectiveness. Zinc ions are effective antimicrobial agents even at low concentrations. Gastroenteritis is strongly attenuated by ingestion of zinc and this effect could be due to direct antimicrobial action of the zinc ions in the gastrointestinal tract or to the absorption of the zinc and re-release from immune cells [all granulocytes secrete zinc, or both. Cells in the salivary gland, prostate, immune system and intestine use Zn signaling as one way to communicate with other cells. In the brain, zinc is stored in specific synaptic vesicles by glutamatergic neurons and can modulate brain excitability. It plays a key role in synaptic plasticity and so in learning. It also can be a neurotoxin, suggesting zinc homeostasis plays a critical role in normal functioning of the brain and central nervous system.
After gaining access to the circulatory system, nanoparticles can be distributed throughout the body and to specific organs. Zinc, both in elemental or in its salt forms, has been used as a therapeutic modality for centuries. ZnO is an effective treatment for acrodermatitis enteropathica, a genetic disorder affecting zinc absorption that was previously fatal to babies born with it. Typically, physiological levels of zinc are recognized to be important for a variety of normal growth and developmental processes, as well as regulation of the immune system by controlling the activity of many different types of enzymes including transcription factors, metalloproteinases, and polymerases. ZnO nanowires have been shown to be biodegradable and to eventually dissolve into ions that can be absorbed by the body and become part of the nutritional cycle. Consumption of excess zinc can cause ataxia, lethargy and copper deficiency. Zinc is an essential trace element, necessary for plants, animals, and microorganisms.
There are 2-4 grams of Zn distributed throughout the human body. Most zinc is in the brain, muscle, bones, kidney, and liver, with the highest concentrations in the prostate and parts of the eye. It is the second most abundant transition metal in organisms after iron and it is the only metal which appears in all enzyme classes.
The electrostatic characteristics of ZnO nanoparticles are another useful feature for biomedical applications. Zinc oxide nanoparticles typically have neutral hydroxyl groups attached to their surface, which plays a key role in their surface charge behavior. In the aqueous medium and at high pH, the chemisorbed protons (H+) move out from the particle surface leaving a negatively charged surface with partially bonded oxygen atoms (ZnO−). At lower pH, protons from the environment are likely transferred to the particle surface, leading to a positive charge from surface ZnOH2+ groups. The isoelectric point of 9–10 indicates that ZnO nanoparticles will have a strong positive surface charge under physiological conditions.
ZnO is capable of operating effectively and efficiently for wastewater treatment, which has been discussed KFSSI along with other nanotechnology routes that can be useful for water treatments. Multifunctional photocatalytic membranes using ZnO nanostructures are considered advantageous over freely suspended nanoparticles due to the ease of its removal from the purified water. Waste treatment options might include removal of the finest contaminants from water (< 300 nm) and nano particles or reactive surface nano coatings with induced specificity to a certain pollutant that destroys or immobilize toxic compounds and pathogens. The ZnO nanoparticles constitute an effective antimicrobial agent against pathogenic microorganisms. Zinc oxide NPs have potential to boost the yield and growth of food crops. The yield of wheat plants grown from seeds which were treated with metal nanoparticles on average increased by 20–25%. ZnO nanostructures have a great advantage to apply to a catalytic reaction process due to their large surface area and high catalytic activity. One-dimensional nanostructures exhibit interesting electronic and optical properties due to their low dimensionality leading to quantum confinement effects. These crystal defects can lead to a large number of electron-hole pairs (e− − h+). The holes are powerful oxidants and can split water molecules derived from the ZnO aqueous environment into H+ and OH−. The conduction band electrons are good reducers and can move to the particle surface to react with dissolved oxygen molecules to generate superoxide radical anions (O2•−), which in turn react with H+ to generate (HO2•) radicals. These HO2• molecules can then produce hydrogen peroxide anions (HO2−) following a subsequent encounter with electrons. Hydrogen peroxide anions can then react with hydrogen ions to produce hydrogen peroxide (H2O2). The colloidal solution of zinc oxide nanoparticles is used as fertilizer. This type of ZnO nanoparticles plays an important role in agriculture. ZnO nanoparticles fertilizer is a plant nutrient, which is more than a fertilizer because it not only supplies nutrients for the plant but also revives the soil to an organic state without the harmful factors of chemical fertilizer. One of the advantages of ZnO nanoparticles is that they can be used in very small amounts. Zinc oxide nano scale treatment (25 nm mean particle size) at 1000 ppm concentration was used which promoted seed germination, seedling vigor, and plant growth and these ZnO nanoparticles also proved to be effective in increasing stem and root growth in peanuts.
Photocatalysis, using nanostructures of metal oxide semiconductors like ZnO, TiO2, WO3, Zn2SnO4, etc. can be an attractive way of water purification as it is capable of removing chemical as well as biological contaminants. A good photocatalyst should absorb light efficiently preferably in the visible or near UV part of the electro- magnetic spectrum. For the synthesis of ZnO nanoparticles, the organometallic process using an alcohol as the medium has been widely accepted. This is because of faster nucleation and successive growth in alcoholic solvent as compared to aqueous solvent resulting in well dispersed spherical particles with narrow size distribution. In various studies and experiments has been proven that nanomaterial’s dried and dissolved in the aqueous solution not showing the same results and properties.
ZnO crystallizes in two main forms, hexagonal wurtzite and cubic zinc blende (ZnS). The wurtzite ((Zn,Fe)S) structure is most stable at ambient conditions and thus most common. The zinc blende form can be stabilized by growing ZnO on substrates with the cubic lattice structure.
In both cases, the zinc and oxide centers are tetrahedral, the most characteristic geometry for Zn(II). ZnO converts to the rocksalt motif at relatively high pressures about 10 GPa. ZnO exhibits a very long lived optical phonon E2(low) with a lifetime as high as 133 ps at 10 K. ZnO has a relatively large direct band gap of ~3.3 eV at room temperature. Advantages associated with a large band gap include higher breakdown voltages, ability to sustain large electric fields, lower electronic noise, and high-temperature and high-power operation. The semiconductor ZnO has gained substantial interest in the research community in part because of its large exciton binding energy (60meV) which could lead to lasing action based on exciton recombination even above room temperature. While ZnO already has many industrial applications owing to its piezoelectric properties and band gap in the near ultraviolet. nO potentially paving the way for efficient room temperature exciton-based emitters, and sharp transitions facilitating very low threshold semiconductor lasers. Nanostructures of ZnO can be synthesized into a variety of morphologies including nanowires, nanorods, tetrapods, nanobelts, nanoflowers, nanoparticles etc. Nanostructures can be obtained at certain conditions, and also with the vapor-liquid-solid method. Certain additives, such as polyethylene glycol or polyethylenimine, can improve the aspect ratio of the ZnO nanowires. Doping of the ZnO nanowires has been achieved by adding other metal nitrates to the growth solution. The morphology of the resulting nanostructures can be tuned by changing the parameters relating to the precursor composition (such as the zinc concentration and pH) or to the thermal treatment, such as the temperature and heating rate. Aligned ZnO nanowires on pre-seeded silicon, glass, and gallium nitride substrates have been grown using aqueous zinc salts such as zinc acetate in basic environments. Pre-seeding substrates with ZnO creates sites for homogeneous nucleation of ZnO crystal during the synthesis. Common pre-seeding methods include in-situ thermal decomposition of zinc acetate crystallites, spincoating of ZnO nanoparticles and the use of physical vapor deposition methods to deposit ZnO thin films. Pre-seeding can be performed in conjunction with the top down patterning methods such as electron beam lithography and nanosphere lithography to designate nucleation sites prior to growth. Aligned ZnO nanowires can be used in dye-sensitized solar cells and field emission devices. The pointed tips of ZnO nanorods result in a strong enhancement of an electric field. Therefore, they can be used as field emitters.
Zinc is an essential element needed by your body in small amounts. We are exposed to zinc compounds in food. Total body zinc in adult males is approximately 2.5g in men and 1.5g in women. The majority of 391 total body zinc, i.s. about 85%, is in muscle and bone. A average zinc intakes ranged from 2.4 to 3.7mg/day in infants (< 1 year of age), from 4.5 to 6.9 mg/day in children aged 1to < 3 years, between 5. 5 and 9.9 mg/day in children aged 3 to < 10 years, between 6.9 and 13.6 mg/day in adolescents (1 to < 18 years), and between 8.1 - 13.5mg/day in adults.
Profound and more accurate increase research ZnO nanoparticles would be required for forwarding development for plasma electronics, environment, animal and human health etc. issues worldwide.
This is a small part of ZnO wonders shortly described from various different sources, studies, and experiments. New information and tests and production methods will be updated very soon.
Zn/CO2 MCP's filtration with low up to 10 µm paper filter gives you Zn/Co2 liquid plasma water.
Usually, red blood cells are a standard size of about 6-8 μm in diameter.
70% of the cancer cells had a cell diameter that was between 17.5 and 21.3 microns.
Bacteria cells are up to 10 µm.
Typically coffee filters are made up of filaments approximately 20 micrometers wide, which allow particles through that are less than approximately 10 to 15 micrometers.
It makes sense for filtration.
Many of our artisan soap bars contain Zinc mineral crystal particles because if their antibacterial and antimicrobial performance, we consider Zinc in soap as salt in kitchen. It plays very important role in skin care and should be promoted for daily use even more.
Thank you for reading.
Your purchases are donations and research contribution for to ''Liquid Plasma Crystals'' research to develop new skin care products and natural supplement extraction methods and use of nature-based plasma energies in the modern world. Our goal is to develop sustainable technologies as green as possible, to use only beneficial ingredients, make products without using extra energy, find best solutions that are efficient for the future of humanity and are sustainable for our dear planet Earth.
Thank you very much for your confidence and support.
You can find out more about plasma concept in skin care and health supplements in knowledge sharing blog posts in liquidplasmacrystals.com site and Facebook page, or follow us on Instagram and Pinterest.
If any questions please feel free to ask.